Tagged: Sleep Review

Narcolepsy Drug Improves On-Road Vehicle Control 0

Narcolepsy Drug Improves On-Road Vehicle Control

Solriamfetol (Sunosi) significantly improved driving performance for patients with narcolepsy and daytime sleepiness due to obstructive sleep apnea, according to a pair of on-road driving studies sponsored by the drugmaker.

In the one-hour driving test, performed two hours after taking 300 mg solriamfetol or placebo, patients with narcolepsy showed less weaving with the active drug (difference in standard deviation of lateral positioning -1.9 cm, 95% CI -6.7 to 2.6, P=0.002), reported Frederick Vinckenbosch, MSc, of Maastricht University in the Netherlands.

Get the full story at medpagetoday.com.

from Sleep Review https://www.sleepreviewmag.com/sleep-disorders/hypersomnias/narcolepsy/narcolepsy-drug-improves-on-road-vehicle-control/…

Investigational Sleep Apnea Drug to Move to Phase 2 Trial 0

Investigational Sleep Apnea Drug to Move to Phase 2 Trial

Apnimed, a clinical-stage pharmaceutical company focused on developing medicines to treat sleep apnea and related disorders, reports the results of a Phase 1 study for a component of the company’s lead combination drug candidate, AD109, which is being explored as a pharmacologic treatment for obstructive sleep apnea (OSA). In this healthy volunteer study, R-oxybutynin, a key component of AD109, demonstrated a favorable pharmacokinetic (PK) profile and was well tolerated with no adverse events related to the study drug.

“Obstructive sleep apnea represents a significant public health problem in the US and around the globe and current treatment options do not meet the needs of patients,” says Larry Miller, MD, Apnimed CEO, in a release. “We believe that AD109, an oral drug candidate dosed once-daily at bedtime, could be a significant breakthrough for these patients by giving them a simple, safe, and effective solution that does not require a CPAP device or surgery. The results from this study support our advancement of this program.

“We look forward to initiating a Phase 2 study with AD109 in Q4 of this year.”


Sleep Apnea Device Developer Signifier Closes $10M Series C Round 0

Sleep Apnea Device Developer Signifier Closes $10M Series C Round

Signifier Medical Technologies, which markets the Snoozeal device for snoring and is developing a device for mild sleep apnea, has closed a circa $10M Series C funding round led by Alan Howard, VC investor and co-founder of Brevan Howard. The proceeds will allow Signifier to invest further in its solutions for patients with sleep-disordered breathing conditions.

The financing round also included participation from James Blair, a career healthcare venture capitalist and Partner/Co-founder of Domain Associates as an additional new investor in Signifier. Existing investors participating in the round included The Pritzker Organization and Signifier’s Chairman Kieran Gallahue, former CEO of both CareFusion and Resmed.

Howard says in a release, “I look for companies that are addressing extensive market opportunities, are rapidly growing, and have experienced leadership teams. I strongly believe Signifier is one of those companies, and I am pleased to support its transformational innovation to address sleep and breathing disorders and chronic care management.”

[RELATED: Have Snoring…Will Treat It]

Joseph Gleberman, managing director of The Pritzker Organization, says in a release, “We are pleased to continue supporting Signifier’s breakthrough …

Fitbit Gets FDA Clearance for ECG App 0

Fitbit Gets FDA Clearance for ECG App

Fitbit has made no secret of its plans to get its fitness trackers US Food and Drug Administration (FDA)-cleared for sleep apnea detection; while not there yet, the company has recently made noteworthy progress on related FDA aspirations.

Fitbit just received 510(k) clearance from the FDA (as well as Conformité Européenne or CE marking in the European Union), for its electrocardiogram (ECG) app to assess heart rhythm for atrial fibrillation (AFib). The Fitbit ECG App, unveiled in Fitbit’s recent fall product launch, will be available in October 2020 to users on Fitbit Sense in the United States, United Kingdom, Germany, Austria, Luxembourg, the Netherlands, Sweden, Switzerland, Czech Republic, Poland, Belgium, Portugal, Romania, Ireland, Italy, Spain, France, Hong Kong, and India.

“Helping people understand and manage their heart health has always been a priority for Fitbit, and our new ECG app is designed for those users who want to assess themselves in the moment and review the reading later with their doctor,” says Eric Friedman, Fitbit co-founder and chief technology officer, in a release. “Early detection of AFib is critical, …

Does Sleep Apnea Put COVID-19 Patients at Increased Risk of Adverse Outcomes? 0

Does Sleep Apnea Put COVID-19 Patients at Increased Risk of Adverse Outcomes?

People who have been diagnosed with obstructive sleep apnea (OSA) could be at increased risk of adverse outcomes from COVID-19, according to a new study from the University of Warwick.

The conclusion is drawn from a systematic review of studies that reported outcomes for COVID-19 patients who were also diagnosed with obstructive sleep apnea. Published in the journal Sleep Medicine Reviews, the review highlights the need to further investigate the impact of the virus on those with the sleep condition and to better identify those currently undiagnosed with it.

Many of the risk factors and comorbidities associated with sleep apnea, such as diabetes, obesity, and hypertension, are similar to those associated with poor COVID-19 outcomes. However, the researchers wanted to investigate whether being diagnosed with OSA conferred an additional risk on top of those factors.

The systematic review looked at eighteen studies up to June 2020 with regards to obstructive sleep apnea and COVID-19, of these eight were mainly related to the risk of death from COVID-19 and ten were related to diagnosis, treatment, and management of sleep apnea. …

Bookmark This American Heart Association Webpage for Cardio-Sleep Education 0

Bookmark This American Heart Association Webpage for Cardio-Sleep Education

With financial support from Jazz Pharmaceuticals plc, the American Heart Association (AHA) will create cardio-sleep-related educational multimedia content. It is available at www.heart.org/en/health-topics/sleep-disorders.

Studies show that more than one-third of Americans do not get the recommended seven hours of sleep per night.1,2 Jazz and the AHA seek to reverse this trend, as it is well established that sleep disorders and disrupted sleep can put people at higher risk for cardiometabolic diseases, including obesity, diabetes, heart attack, stroke, and coronary artery disease.3,4 Adequate, healthy sleep is linked to getting sick less often, staying at a healthy weight, reducing stress, and thinking more clearly.5

“Jazz’s purpose is to innovate to transform the lives of patients, and the American Heart Association’s consumer education aims to positively affect the lives of people struggling with healthy sleep or sleep disorders,” says Bruce Cozadd, chairman and CEO of Jazz Pharmaceuticals, in a release. “We are proud to support the American Heart Association to educate and empower Americans to live healthier lives through the power of sleep with an emphasis on sleep disorders, …

British Sleep Society Provides Sleep-Related Advice During COVID-19 0

British Sleep Society Provides Sleep-Related Advice During COVID-19

The British Sleep Society has released a statement addressing questions and concerns about obstructive sleep apnea, insomnia, and stress and anxiety during the pandemic.

If you think that you cannot use CPAP during a Covid-19 infection, either because you put others at risk or because of difficulties when using it (e.g. coughing), then stopping the CPAP until symptoms improve might be the sensible thing to do. However, you might experience over the next week that OSA related symptoms reoccur and you should continue with your treatment as soon as the infection is over. If you are proposing to stop using CPAP during an infection, you should first discuss
this with your care provider where reasonably possible, by phone or e-mail.


from Sleep Review https://www.sleepreviewmag.com/sleep-health/prevailing-attitudes/academies-associations/british-sleep-society-covid-19/…

MIT Scientists Wirelessly Capture Sleep Position 0

MIT Scientists Wirelessly Capture Sleep Position

MIT researchers have developed a wireless, private way to monitor a person’s sleep postures—whether snoozing on their back, stomach, or sides—using reflected radio signals from a device mounted on a bedroom wall.

The device, called BodyCompass, is a home-ready, radio-frequency-based system to provide sleep data without cameras or sensors attached to the body, according to Shichao Yue, who will introduce the system in a presentation at the UbiComp 2020 conference today. The PhD student has used wireless sensing to study sleep stages and insomnia for several years.

“We thought sleep posture could be another impactful application of our system” for medical monitoring, says Yue, who worked on the project under the supervision of Dina Katabi, a professor in the MIT Computer Science and Artificial Intelligence Laboratory, in a release. Studies show that stomach sleeping increases the risk of sudden death in people with epilepsy, he notes, and sleep posture could also be used to measure the progression of Parkinson’s disease as the condition robs a person of the ability to turn over in bed.

In the future, people might also …

Sleep Apnea Linked with Higher Spine Fracture Risk Among Women 0

Sleep Apnea Linked with Higher Spine Fracture Risk Among Women

Emerging evidence suggests that obstructive sleep apnea (OSA) may negatively affect bone health. Results from a new study published in the Journal of Bone and Mineral Research now indicate that women with history of OSA may face a higher risk of spine, or vertebral, fractures.

Using information from the Nurses’ Health Study, investigators examined data pertaining to 55,264 women without a prior history of bone fractures. OSA was self-reported in 1.3% of participants in 2002 and increased to 3.3% by 2012. Between 2002 and 2014, 461 vertebral fractures and 921 hip fractures occurred.

[RELATED: Sleep Length May Affect Risk of Falls and Fractures]

Women with a history of OSA had a 2-fold higher risk of vertebral fracture relative to those with no OSA history, with the strongest association observed for OSA associated with daytime sleepiness. No association was observed between OSA history and risk of hip fracture.

“Our study provides important evidence at the population level that obstructive sleep apnea may have an adverse impact on bone health that is particularly relevant to the development of vertebral fracture,” says lead …

How Machine Learning Could Transform the Way We Diagnose Narcolepsy 0

How Machine Learning Could Transform the Way We Diagnose Narcolepsy

Researchers at Virtual SLEEP 2020 explained machine learning’s potential in sleep medicine.

By Lisa Spear

Even under the care of a sleep medicine clinician, narcolepsy patients may have a long wait before receiving a correct diagnosis. Researchers think that machine learning and the use of neural network analysis could speed up the diagnostic process, and pave the way for more precise care.

“Within the next few years, sleep scoring by technician will be replaced by automatic deep learning networks that will automatically annotate the sleep study and the task of the technician or doctor will only be to verify the event,” sleep scientist Emmanuel Mignot, MD, director of the Stanford Center for Narcolepsy, said during a presentation.

During Virtual SLEEP 2020, Mignot and a panel of other experts spoke about the future of artificial intelligence and machine learning in sleep medicine.

The panel discussed how these tools could potentially improve treatment for countless patients, lead to the use of phenotyping for diagnosing obstructive sleep apnea, and speed up the diagnostic process for those who experience narcolepsy with cataplexy, also …