Tagged: Sleep Review

Interim Results Released for Phase IIa Study of Cannabinoid-based Drug for Obstructive Sleep Apnea 0

Interim Results Released for Phase IIa Study of Cannabinoid-based Drug for Obstructive Sleep Apnea

Therapix Biosciences Ltd, a specialty, clinical-stage pharmaceutical company focusing on the development of cannabinoid-based treatments, released interim results from its Phase IIa clinical study at Assuta Medical Center in Israel. The results suggest that THX-110, a combination of dronabinol (∆-9-tetrahydracannabinol) and CannAmide (palmitoylethanolamide, or PEA), positively affects symptoms in adult subjects with obstructive sleep apnea (OSA). The study is being conducted under the leadership of Yaron Dagan, MD, MSc, head of the Sleep Medicine Institute at Assuta, and principal investigator, Dr Lilach Kemer.

This Phase IIa clinical study is an open label study, which includes 30 patients diagnosed with OSA, to evaluate the safety, tolerability, and efficacy of once daily oral administration of THX-110. The interim report summarizes the data from the first 7 patients which completed the study per protocol and one patient who dropped out from the study early due to adverse events (dizziness). Out of the 7 patients who completed the study, 4 patients exhibited significant improvement in all assessed study parameters, including reduction in apnea-hypopnea index (AHI) scale and an improvement in oxygen desaturation index (ODI),

Adults with Sleep Apnea More Likely to Experience Involuntary Job Loss 0

Adults with Sleep Apnea More Likely to Experience Involuntary Job Loss

Recently unemployed people with undiagnosed obstructive sleep apnea have a higher risk of having lost a job multiple times, according to preliminary results from a new study presented at SLEEP 2019.

Results show that individuals with undiagnosed obstructive sleep apnea were more likely to have experienced multiple involuntary job losses. Compared to participants who did not have sleep apnea, those with moderate-to-severe sleep apnea were more than twice as likely to have a history of multiple job layoffs or firings.

“These results suggest that undetected obstructive sleep apnea could have long-term, negative effects on vocational functioning,” says principal investigator Patricia Haynes, PhD, an associate professor in the Department of Health Promotion Sciences at the University of Arizona in Tucson, in a release.

This analysis of data from the ongoing, prospective Assessing Daily Activity Patterns through occupational Transitions (ADAPT) study involved 261 participants with an average age of 41 years; 58% were women. Seventy-three percent received hourly wages rather than a salary, and about 45% of participants had a history of multiple job losses. Breathing during sleep was evaluated with

F&P SleepStyle CPAP 0

F&P SleepStyle CPAP

Fisher & Paykel Healthcare has made its F&P SleepStyle CPAP available to the United States market. The positive airway pressure device initially launched in New Zealand and Australia in 2017.

F&P SleepStyle strives to strike a balance between comfort and effective treatment by including an auto algorithm with central apnea detection and a range of comfort options. Features include an easy-access chamber, user-friendly menu, large and responsive menu buttons, built-in connectivity options and a quiet, integrated design. Expiratory relief of CPAP pressure during exhalation is also provided.

The device includes ThermoSmart humidification featuring a heated breathing tube with AirSpiral technology to minimise condensation, and SensAwake, which detects wakefulness and automatically reduces treatment pressure to a comfortable level.

Built-in cellular and Bluetooth connectivity options ensure both patients and clinicians can receive information . Patients are able to track their own progress and receive troubleshooting tips using a mobile app of the same name (“F&P SleepStyle”). The F&P InfoSmart patient management system automatically highlights patients who need their clinician’s attention.

from Sleep Review http://www.sleepreviewmag.com/2019/06/fp-sleepstyle-cpap/…

Sleep Apnea More Common in Americas than Previously Thought 0

Sleep Apnea More Common in Americas than Previously Thought

Roughly 170 million people across North and South America have sleep apnea, according to a study ResMed presented at SLEEP 2019.

The study, a deeper analysis of ResMed’s 2018 finding that 936 million people worldwide have sleep apnea, concludes that:

  • 170 million people in North and South America (37% of adults) have sleep apnea, based on the AASM 2012 criteria—a “conservative” estimate.
  • 3 countries with the highest number of cases are the United States (54 million), Brazil (49 million), and Colombia (11 million).

“Previous estimates stated 100 million worldwide have sleep apnea. Now we know it’s nearly double that in just the Americas alone,” says study coauthor and ResMed chief medical officer Carlos M. Nunez, MD, in a release. “Given how common sleep apnea is, especially among people with other common diseases, doctors should screen their high-risk patients and help those who are diagnosed get onto life-changing treatment as soon as possible.”

The gold standard treatment for sleep apnea is a positive airway pressure (PAP) device that prevents the intermittent suffocation associated with sleep apnea by blowing a mild stream

Commission that Improves Health Care Quality on Jails Adopts Adolescent Sleep Hygiene Position Statement 0

Commission that Improves Health Care Quality on Jails Adopts Adolescent Sleep Hygiene Position Statement

The mission of the National Commission on Correctional Health Care (NCCHC) is to improve the quality of health care in jails, prisons, and juvenile confinement facilities. Earlier this year, its board of directors adopted a position statement on adolescent sleep hygiene.

Adolescent insomnia is often related to medical comorbidities (including sleep apnea, particularly among obese youth and those who snore loudly) as well as the following risk factors often found in incarcerated youth:

  • Psychological conditions (e.g., attention-deficit/hyperactivity disorder, posttraumatic stress disorder, anxiety disorders, depressive and other mood disorders)
  • Poor sleep hygiene (e.g., inconsistent sleep schedules, caffeine)
  • Acute stress/family disorganization
  • Substance use (especially marijuana, alcohol, psychostimulants)

Read the position statement at ncchc.org

from Sleep Review http://www.sleepreviewmag.com/2019/06/commission-improves-health-care-quality-jails-adopts-adolescent-sleep-hygiene-position-statement/…

Sleep Apnea Can Lead to Other Problems for Kids, Doctor Warns 0

Sleep Apnea Can Lead to Other Problems for Kids, Doctor Warns

If not diagnosed early, children can be unfairly labeled with a learning disability or lack of emotional growth, reports Fox13.

“Imagine a child not getting good quality sleep at night,” Dr. Ortiz added. “They are not going to be able to do well at school; they aren’t going to interact well with their peers. That can change their whole lives.”

from Sleep Review http://www.sleepreviewmag.com/2019/06/sleep-apnea-can-lead-to-other-problems-for-kids/…

Crossword Puzzle: Sleep Medicine-Themed Clues (June 2019) 0

Crossword Puzzle: Sleep Medicine-Themed Clues (June 2019)

Can you solve this sleep medicine-themed crossword puzzle, designed specifically for Sleep Review readers? A hard copy published in the June/July 2019 issue.

0619 Crossword

Click on the thumbnail or 0619 Crossword to open a printable PDF.


1 WHO suggested this activity as an alternative to screen time for children, in addition to reading, storytelling, and singing
5 It drives a CPAP
8 Disorder where breathing stops and starts during sleep due to the brain not sending adequate signals to breathing muscles, abbr.
10 Craving
11 Connector used during sleep study
12 Responsibility
13 Time of arrival, abbr.
15 Motionless
17 Series of repeating events, such as stages of sleep
18 Discharge, as a nose
19 Stopped sleeping
20 Shows signs of waking
22 Close to, abbr.
24 Ocean motions
26 Origins
28 Government hospital, abbr.
29 Makers of the travel-friendly Z2 CPAP
32 Most common form of treatment for sleep apnea, abbr.
33 Ending from breath and sleep
35 Volcanic material that can cause severe air pollution
36 Basketball organization, abbr.
37 Susceptibility to a substance that

Opioids Are Not Sleep Aids—They Can Actually Worsen Sleep 0

Opioids Are Not Sleep Aids—They Can Actually Worsen Sleep

Evidence that taking opioids will help people with chronic pain to sleep better is limited and of poor quality, according to an interdisciplinary team of psychologists and medics from the University of Warwick in partnership with Lausanne University Hospital, Switzerland.

Many people suffering from long-term chronic pain use opioids as a sleep aid to take away pain and stop their sleep being disrupted. However, a new study led by the Department of Psychology at the University of Warwick with Warwick Medical School suggests that not enough research has been done to assess the benefits and risks of using painkillers for the purpose of improving sleep quality.

Their study, a systematic review of existing research on the effects of opioids on sleep, has been published in Sleep Medicine Reviews.

Sleep disruption is a particularly frequent issue for patients with chronic pain, with a vicious cycle building between bad nights and increased pain. Patients with chronic pain are often empirically prescribed opioids to reduce their pain enough to get a good night’s sleep, but there has been little investigation of whether

Temporary Oral Appliances for Sleep Apnea Comparison Guide (June 2019) 0

Temporary Oral Appliances for Sleep Apnea Comparison Guide (June 2019)

Temporary Oral Appliances

Compare 6 temporary oral appliances (also known as transitional, interim, or trial appliances) side-by-side. Click on the thumbnail or 0619 Temporary Oral Appliances to open the guide at a legible size or print it.

The guide compares features such as FDA status, how it works, time to fit, fitting description, adjustment description, materials, efficacy data, predictive value data, warranty, estimated useful life, payer reimbursement status, and research supporting the appliance for the following devices: Airway Management myTAP, Advanced Brain Monitoring Inc Apnea Guard, Glidewell Laboratories Silent Nite sl, BlueSom BluePro, Healthy Start/Ortho-Tain Snore-Cure, SomnoMed Inc SomnoDent ALPHA.

Also, see our Custom Oral Appliances for Sleep Apnea Comparison Guide.

A version of this comparison guide published in Sleep Review‘s June/July 2019 issue. Information based on data submitted by oral appliance marketers. Sleep Review strives for accuracy but cannot be held responsible for claims made by marketers. All temporary oral appliances may not be included. E-mail sroy[at]medqor.com to be considered for the next update.

from Sleep Review http://www.sleepreviewmag.com/2019/06/temporary-oral-appliances/…

William Shatner Is SoClean Spokesperson and Ambassador 0

William Shatner Is SoClean Spokesperson and Ambassador

Actor and comedian William Shatner—a CPAP user and SoClean customer himself—will serve as an ambassador and spokesperson for SoClean’s automated CPAP cleaner and sanitizer.

Dean Marcarelli, CMO of SoClean, says in a release, “When identifying a celebrity spokesperson, it was important to us to partner with someone whose CPAP experience had really improved as a result of the SoClean. Mr Shatner is an ideal SoClean spokesperson and ambassador because he can speak authentically about his enthusiasm for the SoClean, helping us reach more CPAP users around the world.”

The first television advertisements featuring Shatner will air this month, helping SoClean advance its mission to improve the lives of people with obstructive sleep apnea (OSA). Additionally, Shatner’s presence will be seen across SoClean’s YouTube, Twitter, Facebook, LinkedIn, and Instagram platforms.

“After I was diagnosed with sleep apnea 10 years ago, my CPAP machine changed my life,” Shatner says. “But I never really understood how important it was to clean it every day to prevent germs and bacteria. That’s why I love my SoClean—it makes it simple to keep the CPAP sanitized.”