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Interim Results Released for Phase IIa Study of Cannabinoid-based Drug for Obstructive Sleep Apnea 0

Interim Results Released for Phase IIa Study of Cannabinoid-based Drug for Obstructive Sleep Apnea

Therapix Biosciences Ltd, a specialty, clinical-stage pharmaceutical company focusing on the development of cannabinoid-based treatments, released interim results from its Phase IIa clinical study at Assuta Medical Center in Israel. The results suggest that THX-110, a combination of dronabinol (∆-9-tetrahydracannabinol) and CannAmide (palmitoylethanolamide, or PEA), positively affects symptoms in adult subjects with obstructive sleep apnea (OSA). The study is being conducted under the leadership of Yaron Dagan, MD, MSc, head of the Sleep Medicine Institute at Assuta, and principal investigator, Dr Lilach Kemer.

This Phase IIa clinical study is an open label study, which includes 30 patients diagnosed with OSA, to evaluate the safety, tolerability, and efficacy of once daily oral administration of THX-110. The interim report summarizes the data from the first 7 patients which completed the study per protocol and one patient who dropped out from the study early due to adverse events (dizziness). Out of the 7 patients who completed the study, 4 patients exhibited significant improvement in all assessed study parameters, including reduction in apnea-hypopnea index (AHI) scale and an improvement in oxygen desaturation index (ODI),

Adults with Sleep Apnea More Likely to Experience Involuntary Job Loss 0

Adults with Sleep Apnea More Likely to Experience Involuntary Job Loss

Recently unemployed people with undiagnosed obstructive sleep apnea have a higher risk of having lost a job multiple times, according to preliminary results from a new study presented at SLEEP 2019.

Results show that individuals with undiagnosed obstructive sleep apnea were more likely to have experienced multiple involuntary job losses. Compared to participants who did not have sleep apnea, those with moderate-to-severe sleep apnea were more than twice as likely to have a history of multiple job layoffs or firings.

“These results suggest that undetected obstructive sleep apnea could have long-term, negative effects on vocational functioning,” says principal investigator Patricia Haynes, PhD, an associate professor in the Department of Health Promotion Sciences at the University of Arizona in Tucson, in a release.

This analysis of data from the ongoing, prospective Assessing Daily Activity Patterns through occupational Transitions (ADAPT) study involved 261 participants with an average age of 41 years; 58% were women. Seventy-three percent received hourly wages rather than a salary, and about 45% of participants had a history of multiple job losses. Breathing during sleep was evaluated with

F&P SleepStyle CPAP 0

F&P SleepStyle CPAP

Fisher & Paykel Healthcare has made its F&P SleepStyle CPAP available to the United States market. The positive airway pressure device initially launched in New Zealand and Australia in 2017.

F&P SleepStyle strives to strike a balance between comfort and effective treatment by including an auto algorithm with central apnea detection and a range of comfort options. Features include an easy-access chamber, user-friendly menu, large and responsive menu buttons, built-in connectivity options and a quiet, integrated design. Expiratory relief of CPAP pressure during exhalation is also provided.

The device includes ThermoSmart humidification featuring a heated breathing tube with AirSpiral technology to minimise condensation, and SensAwake, which detects wakefulness and automatically reduces treatment pressure to a comfortable level.

Built-in cellular and Bluetooth connectivity options ensure both patients and clinicians can receive information . Patients are able to track their own progress and receive troubleshooting tips using a mobile app of the same name (“F&P SleepStyle”). The F&P InfoSmart patient management system automatically highlights patients who need their clinician’s attention.

from Sleep Review…

Sleep Apnea More Common in Americas than Previously Thought 0

Sleep Apnea More Common in Americas than Previously Thought

Roughly 170 million people across North and South America have sleep apnea, according to a study ResMed presented at SLEEP 2019.

The study, a deeper analysis of ResMed’s 2018 finding that 936 million people worldwide have sleep apnea, concludes that:

  • 170 million people in North and South America (37% of adults) have sleep apnea, based on the AASM 2012 criteria—a “conservative” estimate.
  • 3 countries with the highest number of cases are the United States (54 million), Brazil (49 million), and Colombia (11 million).

“Previous estimates stated 100 million worldwide have sleep apnea. Now we know it’s nearly double that in just the Americas alone,” says study coauthor and ResMed chief medical officer Carlos M. Nunez, MD, in a release. “Given how common sleep apnea is, especially among people with other common diseases, doctors should screen their high-risk patients and help those who are diagnosed get onto life-changing treatment as soon as possible.”

The gold standard treatment for sleep apnea is a positive airway pressure (PAP) device that prevents the intermittent suffocation associated with sleep apnea by blowing a mild stream

The 2019 MAD Mouthpiece Award Goes To ZQuiet 0

The 2019 MAD Mouthpiece Award Goes To ZQuiet

The winner is …ZQuiet. Yes! ZQuiet wins the award for being the best MAD mouthpiece for 2019. Awarded  by The Snoring Mouthpiece Review, ZQuiet tops a long list of MAD mouthpieces in the market.

As part of its commitment to offering unbiased, rigorous reviews of snoring cessation products such as mouthpieces, pillows, chin straps and software applications, The Snoring Mouthpiece Review has awarded the ZQuiet® its 2019 MAD Mouthpiece of the Year, beating out other rivals in the category.


MAD stands for Mandibular Advancement Device and it is one of the two categories of snoring mouthpieces. The second category is composed of the TSD or Tongue Stabilizing Devices.

Snoring mouthpieces are typically categorized in one of two ways: 1. MAD or Mandibular Advancement Device, and 2. TSD or Tongue Stabilizing Devices. The MAD category remains the most popular in the realm of anti snoring mouthpieces, with TSD devices quickly gaining ground thanks to the key star in the category, the Good Morning Snore Solution.

The MAD category features literally 15-20 other major mouthpiece manufacturers doing battle for

How Floating’s Pain-Relieving Powers Can Help Sleep 0

How Floating’s Pain-Relieving Powers Can Help Sleep

I’ve been talking lately about the fascinating, encouraging science around floatation therapy and how this peaceful, meditation-like practice can improve sleep and a whole range of health issues, mental, emotional and physical. Last time, I focused on the benefits of floating for psychological health. Today, I’m looking at what the science tells us about floatation therapy’s potential benefits in alleviating physical pain.

If you’ve ever drawn a bath at the end of a long day to ease sore muscles, found physical and mental relaxation in a lap session swim, and or sought relief in the calm waters of a lake or the rhythmic waves of the ocean, you know the power that water can have in relieving physical and psychological tension. Floatation therapy harnesses that essential power and combines it with the deeply relaxing properties of magnesium, and the calming, centering capabilities of restricted environmental stimulation therapy, or REST. For a refresher on how floating works, read my initial article, here.

Float therapy for pain relief

The characteristics of floatation therapy make it a strong fit for treating

Commission that Improves Health Care Quality on Jails Adopts Adolescent Sleep Hygiene Position Statement 0

Commission that Improves Health Care Quality on Jails Adopts Adolescent Sleep Hygiene Position Statement

The mission of the National Commission on Correctional Health Care (NCCHC) is to improve the quality of health care in jails, prisons, and juvenile confinement facilities. Earlier this year, its board of directors adopted a position statement on adolescent sleep hygiene.

Adolescent insomnia is often related to medical comorbidities (including sleep apnea, particularly among obese youth and those who snore loudly) as well as the following risk factors often found in incarcerated youth:

  • Psychological conditions (e.g., attention-deficit/hyperactivity disorder, posttraumatic stress disorder, anxiety disorders, depressive and other mood disorders)
  • Poor sleep hygiene (e.g., inconsistent sleep schedules, caffeine)
  • Acute stress/family disorganization
  • Substance use (especially marijuana, alcohol, psychostimulants)

Read the position statement at

from Sleep Review…

Sleep Apnea Can Lead to Other Problems for Kids, Doctor Warns 0

Sleep Apnea Can Lead to Other Problems for Kids, Doctor Warns

If not diagnosed early, children can be unfairly labeled with a learning disability or lack of emotional growth, reports Fox13.

“Imagine a child not getting good quality sleep at night,” Dr. Ortiz added. “They are not going to be able to do well at school; they aren’t going to interact well with their peers. That can change their whole lives.”

from Sleep Review…

Crossword Puzzle: Sleep Medicine-Themed Clues (June 2019) 0

Crossword Puzzle: Sleep Medicine-Themed Clues (June 2019)

Can you solve this sleep medicine-themed crossword puzzle, designed specifically for Sleep Review readers? A hard copy published in the June/July 2019 issue.

0619 Crossword

Click on the thumbnail or 0619 Crossword to open a printable PDF.


1 WHO suggested this activity as an alternative to screen time for children, in addition to reading, storytelling, and singing
5 It drives a CPAP
8 Disorder where breathing stops and starts during sleep due to the brain not sending adequate signals to breathing muscles, abbr.
10 Craving
11 Connector used during sleep study
12 Responsibility
13 Time of arrival, abbr.
15 Motionless
17 Series of repeating events, such as stages of sleep
18 Discharge, as a nose
19 Stopped sleeping
20 Shows signs of waking
22 Close to, abbr.
24 Ocean motions
26 Origins
28 Government hospital, abbr.
29 Makers of the travel-friendly Z2 CPAP
32 Most common form of treatment for sleep apnea, abbr.
33 Ending from breath and sleep
35 Volcanic material that can cause severe air pollution
36 Basketball organization, abbr.
37 Susceptibility to a substance that

Is It Bad To Watch TV Before Bed? 0

Is It Bad To Watch TV Before Bed?

This has been a great week. I was asked to be on Headline News to talk about a new study looking at how light in your bedroom can lead to weight gain; more on that in a second. I also gave a lecture in San Francisco to a global Chief Marketing Officer conference. Finally, I met with celebrity fitness trainer Peter Park on the important combination of sleep and exercise!

On Headline News I talked about a large scale study where it was discovered that people who slept with a light or the television on shared two similar characteristics that were different from those who slept in total darkness:

  • These people tended to already be obese
  • Over a 5-year period, compared to similar people, they gained almost 11 lbs

This was only a correlational study, meaning that we cannot say that having a light on will cause the weight gain. We can only say that those people tended to be the ones who gained weight. In another study published in 2016, under more controlled conditions, similar results were observed.

So, …