Gout and Sleep Apnea: It’s Complicated
Risk is increased with comorbidities such as heart failure and renal impairment, reports MedPage Today.
“First, OSA-induced hypoxemia causes a rise in adenosine triphosphate degradation, which eventually increases purine concentrations and their end product, uric acid. Second, hypercapnia and acidosis caused by OSA could influence the likelihood of monosodium urate precipitation. Third, excretion of lactic acid, generated during the hypoxic episodes in OSA, could result in a higher renal reabsorption of uric acid,” de Vries and co-authors explained.
from Sleep Review https://www.sleepreviewmag.com/sleep-disorders/breathing-disorders/obstructive-sleep-apnea/gout-and-sleep-apnea-its-complicated/