Poor Sleep Efficiency Linked to Lower Cognitive Functioning in People with Diabetes

A study published in the journal Acta Diabetologica reports that people with diabetes and prediabetes who have lower sleep efficiency—a measure of how much time in bed is actually spent sleeping—have poorer cognitive function than those with better sleep efficiency.

“The cognitive effects of poor sleep quality are worse for this population, which we know is already at risk for developing cognitive impairment as a result of having diabetes,” says Sirimon Reutrakul, MD, associate professor of endocrinology, diabetes, and metabolism in the University of Illinois at Chicago College of Medicine and corresponding author on the paper, in a release.

In previous studies, diabetes has been linked to cognitive impairment and an increased risk for dementia. Other studies have found that sleep disturbances, which are common in people with diabetes, are also linked to cognitive impairment.

Researchers led by Reutrakul investigated the relationship between sleep and cognitive function in patients with abnormal glucose tolerance—patients with impaired glucose tolerance indicative of prediabetes, as well as patients with clinically diagnosed diabetes.

A total of 162 participants were involved in the study: 81 with Type 2 diabetes and 81 with prediabetes. The average age of the participants was 54.8 years. Sleep duration and sleep efficiency were obtained for each participant through 7-day actigraphy recordings.

Cognitive function was assessed using a questionnaire called the Montreal Cognitive Assessment, or MoCA. All participants were evaluated for obstructive sleep apnea.

The researchers found that the average sleep duration was 6 hours per night, and the average sleep efficiency was 82.7% (meaning that 82.7% of time spent in bed was spent in sleep).

They found that the duration of sleep, as well as the severity of diagnosed obstructive sleep apnea, were not related to cognitive function as measured by MoCA. However, better sleep efficiency was associated with better cognitive function scores for participants with diabetes and prediabetes. They also found that having diabetes was associated with lower cognitive function scores.

“Our study shows that lower sleep efficiency is independently associated with lower cognitive function in patients with abnormal glucose tolerance,” says Reutrakul. “Further studies should look at whether helping these patients sleep better could improve cognitive function.”

Sunee Saetung, Dr Hataikarn Nimitphong, Dr Nantaporn Siwasaranond, Rungtip Sumritsopak, Dr Panitha Jindahra, Dr Orapitchaya Krairit, Ammarin Thakkinstian, and Dr Thunyarat Anothaisintawee of Mahidol University, Bangkok, are co-authors on the paper.

This research was funded by a grant from Mahidol University, Bangkok; a grant from the Health Systems Research Institute, Thailand; grant 60-042 from the National Research Council of Thailand; and grant MSIP 0000-349 from the Investigator-Initiated Studies Program of Merck Sharp & Dohmne Corp.

from Sleep Review http://www.sleepreviewmag.com/2018/09/poor-sleep-efficiency-linked-lower-cognitive-functioning-people-diabetes/

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